Hepatitis C virus genotype 4 therapy: progress and challenges
نویسندگان
چکیده
منابع مشابه
Hepatitis C virus genotype 4 therapy: progress and challenges.
The hepatitis C virus genotype 4 (HCV-4) is prevalent in Egypt, the Middle East and Africa. Recently, the epidemiology of HCV-4 has changed and this genotype has begun to cross borders and spread to several regions in Europe through immigration and injection drug use. HCV-4 has been considered a difficult-to-treat genotype based on the low sustained virological response (SVR) rates obtained wit...
متن کاملheterogeneity and new epitopes of hepatitis c virus genotype 4
results the present work figured out that the heterogeneity of the quasispecies of our local strains 4a was high showing up 15% diversity. this study also showed four glycosylation sites that play an important role in the entry of the virus and protein folding. besides, different epitpoes were identified in different regions of the e1 and e2 domains; a finding which would help in determining th...
متن کاملDevelopment of hepatitis C virus vaccines: challenges and progress.
Development of an effective vaccine against the hepatitis C virus (HCV) has long been defined as a difficult challenge due to the considerable variability of this RNA virus and the observation that convalescent humans and chimpanzees could be re-infected after re-exposure. On the other hand, progress in the understanding of antiviral immune responses in patients with viral clearance has elucida...
متن کاملHeterogeneity and New Epitopes of Hepatitis C Virus Genotype 4
BACKGROUND Hepatitis C virus (HCV) was found to have a major role in human liver disease by its ability to face the host-cell defenses and the immune system. Heterogeneity of HCV was the key for its adaptation to its host and represented a significant hurdle for the development of both effective vaccines as well as for novel therapeutic interventions. OBJECTIVES Due to the heterogeneity of HC...
متن کاملHepatitis C virus and skin
Nowadays viral hepatitis is one of the most common and important causes of chronic liver disorders in the world. Extrahepatic manifestations of viral hepatitis consist a main part of the disease. The main viruses causing hepatitis include Hepatitis A, B and C viruses. Herein common skin manifestations in hepatitis C virus (HCV) are discussed. Chronic hepatitis causes skin disorders both directl...
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ژورنال
عنوان ژورنال: Liver International
سال: 2011
ISSN: 1478-3223
DOI: 10.1111/j.1478-3231.2010.02385.x